With my VR6 I started with fully synthetic Fuchs Titan Super GTO 10-40w but I did find the oil consumption was pretty high at almost 1L / 1000km. I pretty much just kept a 1L bottle in the car and poured it in every second tank of fuel.
I then switched to Castrol GTX 2 20W50 (This is now labelled as GTX in a grey bottle, there is also a white bottle of "GTX" but it's slightly different). With the GTX2 I didn't burn as much oil and otherwise had no adverse effects. The VR6 does run pretty hot after all.
As for changes, I did mine every 6 months, of nothing else it gives you a good excuse to crawl under the car and make sure it's all still together
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