There can be differences, particularly the fuel in major metropolitan areas and fuel in regional areas. It can also differ from region to region.
As an example, in winter, areas likely to see temperatures getting close to zero will have a special winterised fuel. If you use a non-winterised fuel (particularly diesel), you can end up with fuel that does not stray properly and result in increased fuel consumption.
The single most significant thing driving fuel consumption is the driver and how the accelerator pedal is used. Cruise control is great at overcoming even the best driver on the accelerator
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